MOTS-c 10mg

$65.00

Category: Peptides

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MOTS-c Mitochondrial Research Peptide (10mg Lyophilized Powder) | mot-c peptide for sale

Notice: All products provided by Onyx Labs are strictly intended for laboratory research and analytical testing purposes only. They are not intended for human or animal consumption, diagnostic testing, clinical administration, or therapeutic use.

High-Purity MOTS-c Peptide (16-Amino Acid Mitochondrial Signal)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid micropeptide encoded within the mitochondrial genome rather than the nuclear genome. Functioning as a novel mitochondrial-derived peptide (MDP), MOTS-c acts as a endocrine-like signaling factor that translocates to the nucleus under metabolic stress to regulate nuclear gene expression.

In metabolic and cellular signaling literature, MOTS-c is extensively studied for its capacity to activate AMP-activated protein kinase (AMPK), enhance insulin sensitivity, regulate systemic glucose homeostasis, promote fatty acid oxidation, and prevent metabolic decline associated with cellular aging.

Why Source Mot-C Peptide For Sale Research Materials at Onyx Labs?

When conducting quantitative assays on mitochondrial bioenergetics or metabolic signaling pathways, receiving synthesis-verified sequence profiles and exact batch purity is critical to scientific reproducibility.

Analytical Purity & Testing Standards

Researchers evaluating suppliers of mot-c peptide for sale choose Onyx Labs for our unwavering commitment to laboratory transparency. Every batch of MOTS-c undergoes rigorous High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) testing to confirm a sequence purity rating of ≥98%.

Advanced Lyophilization & Cold-Chain Stability

Because short mitochondrial peptides can be susceptible to enzymatic breakdown and structural degradation in liquid state, our 10mg MOTS-c vials are sterile-filtered, lyophilized into a stable white cake, and vacuum-sealed under strict climate-controlled conditions to preserve peptide stability during transport and storage.

Mechanisms of Action & Metabolic Signaling Pathways

MOTS-c operates through novel nuclear-mitochondrial communication cascades:

                    ┌──► AMPK Phosphorylation (Triggers Cellular Energy Sensing)
                    │
MOTS-c Micropeptide ┼──► Nuclear Translocation (Modulates Stress-Response Gene Expression)
                    │
                    └──► Folate-Purine Synthesis Regulation & Glucose Transporter (GLUT4) Upregulation

1. AMPK Activation & Metabolic Homeostasis

MOTS-c targets the folate cycle to inhibit 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase (ATIC), leading to the accumulation of AICAR and subsequent phosphorylation of AMPK. This master metabolic switch enhances cellular glucose uptake and fatty acid oxidation.

2. Nuclear Translocation Under Stress

In response to metabolic or oxidative stress, MOTS-c translocates directly to the nucleus, where it interacts with transcription factors such as NRF2 (Nuclear Factor Erythroid 2-Related Factor 2) to upregulate stress-response and antioxidant gene networks.

3. Exercise Mimetic Dynamics

In exercise physiology research, MOTS-c is investigated as a mitochondrial “exercise mimetic” due to its ability to improve muscle insulin sensitivity, increase skeletal muscle GLUT4 translocation, and enhance metabolic flexibility.

Technical Specifications & Storage Guidelines

Parameter	Specification
Product Name	MOTS-c (Mitochondrial-Derived Peptide)
Sequence	Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
CAS Number	1627580-64-6
Molecular Weight	2174.6 g/mol
Purity Grade	≥98% (HPLC & Mass Spec Verified)
Physical Appearance	White Lyophilized Powder
Storage (Unreconstituted)	Store at -20°C (-4°F) in a dark, dry environment. Stable for up to 24 months.
Storage (Reconstituted)	Refrigerate at 2°C – 8°C (36°F – 46°F) and utilize within 30 days.

FAQ: Handling & Mot-C Peptide For Sale Reconstitution

What diluent is recommended for reconstituting MOTS-c 10mg?

For standard laboratory protocol preparation, reconstitute the lyophilized cake using Bacteriostatic Water (BAC Water) or sterile 0.9% Sodium Chloride. Direct the liquid slowly along the inner glass wall of the vial to ensure smooth dissolution without shearing the 16-amino acid sequence.

How do I access the Certificate of Analysis (CoA) for my MOTS-c order?

When looking for a verified source when searching for mot-c peptide for sale, transparency is essential. Enter your batch tracking number in the MyOnyx portal or visit our dedicated Lab Results page to view complete Mass Spec and HPLC chromatograms for your specific lot.