GLP-3 RT

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SKU: N/A Category: Peptides

GLP-3 RT Research Peptide (10mg Lyophilized Powder)

Notice: All products offered by Onyx Labs are strictly intended for laboratory research and analytical testing purposes only. They are not intended for human or animal consumption, diagnostic applications, or therapeutic administration.

High-Purity GLP-3 RT (Triple Agonist Compound)

GLP-3 RT (also studied under the research designation LY3437943 or Retatrutide) is a 39-amino acid single-chain peptide that functions as a single-molecule triple agonist. Unlike traditional single or dual incretin mimetics, GLP-3 RT simultaneously activates three distinct metabolic signaling pathways:

GLP-1 (Glucagon-Like Peptide-1)
GIP (Glucose-Dependent Insulinotropic Polypeptide)
GCGR (Glucagon Receptor)

Synthesized with a C18 fatty diacid chain for extended plasma stability, this compound allows laboratory investigators to study multi-pathway metabolic kinetics, glucose regulation, lipid metabolism, and thermogenic energy expenditure in vitro and in vivo models.

Why Source ION 3R Class Peptides at Onyx Labs?

When conducting high-precision metabolic signaling research, acquiring verified sequence profiles and consistent batch purity is essential for experimental reproducibility.

Analytical Verification for ION 3R Formulations

Researchers seeking ion 3r class compounds select Onyx Labs for our commitment to laboratory transparency. Every batch of GLP-3 RT undergoes multi-stage quality control, including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS), to guarantee an overall purity rating of ≥99%.

Advanced Lyophilization & Cold-Chain Logistics

To preserve structural sequence integrity and prevent oxidation during transport, our ion 3r series peptides are sterile-filtered, lyophilized into a stable matrix, and vacuum-sealed under strict laboratory controls.

Triple-Action Receptor Kinetics Explained

The single-molecule architecture of GLP-3 RT engages three separate endocrine receptor pathways simultaneously:

                     ┌──► GLP-1 Receptor (Appetite & Satiety Pathways)
                     │
GLP-3 RT Molecule ───┼──► GIP Receptor (Adipocyte Lipid & Glucose Kinetics)
                     │
                     └──► GCGR Glucagon Receptor (Hepatic Thermogenesis)

1. GLP-1 Receptor Agonism

Activates central and peripheral GLP-1 signaling pathways, allowing researchers to measure changes in gastric motility, insulin secretion, and nutrient-response dynamics.

2. GIP Receptor Agonism

Simultaneously binds GIP receptors to study adipocyte insulin sensitivity, lipid handling, and potential synergistic responses when paired with GLP-1 activation.

3. Glucagon Receptor (GCGR) Agonism

Engages the glucagon pathway to stimulate mitochondrial fat oxidation and basal energy expenditure models, balanced by the glucose-regulating effects of GLP-1 and GIP activation.

Technical Specifications & Storage Guidelines

Parameter	Specification
Product Name	GLP-3 RT (Research Grade)
Chemical Name / Code	LY3437943 / Retatrutide
CAS Number	2381089-83-2
Molecular Weight	~4,731.32 g/mol
Purity Grade	≥99% (HPLC Verified)
Physical Appearance	White Lyophilized Powder
Storage (Unreconstituted)	Store at -20°C (-4°F) in dark, dry conditions; stable up to 24 months.
Storage (Reconstituted)	Refrigerate at 2°C – 8°C (36°F – 46°F) and utilize within 30 days.

Frequently Asked Questions: ION 3R Handling & Reconstitution

What solvent is recommended for reconstituting GLP-3 RT?

For standard laboratory assay preparations, reconstitute the lyophilized cake using Bacteriostatic Water (BAC Water). Direct the liquid slowly along the inner glass wall of the vial to ensure smooth dissolution without shearing the peptide chain.

How do I access Certificates of Analysis for ION 3R series orders?

Every shipment from Onyx Labs includes a lot tracking number. You can download the complete Mass Spectrometry and HPLC Certificate of Analysis (CoA) for your batch directly through your MyOnyx user account or on our Lab Results page.